A role of ghrelin in neuroendocrine and behavioral responses to stress in mice
- PMID: 11528215
- DOI: 10.1159/000054680
A role of ghrelin in neuroendocrine and behavioral responses to stress in mice
Abstract
Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, was recently identified in the rat stomach. Previous studies have shown that ghrelin potently increases growth hormone release and food intake. We examined the effects of the gastric peptide ghrelin on anxiety-like behavior in association with the hypothalamic-pituitary-adrenal axis in mice. Both intra-third cerebroventricular and intraperitoneal administration of ghrelin potently and significantly induced anxiogenic activities in the elevated plus maze test. Ghrelin gene expression in the stomach was increased by tail pinch stress as well as by starvation stress. Administration of a corticotropin-releasing hormone (CRH) receptor antagonist significantly inhibited ghrelin-induced anxiogenic effects. Peripherally administered ghrelin significantly increased CRH mRNA, but not urocortin mRNA expression in the hypothalamus. Furthermore, intraperitoneal injection of ghrelin produced a significant dose- dependent increase in serum corticosterone levels. These findings suggest that ghrelin may have a role in mediating neuroendocrine and behavioral responses to stressors and that the stomach could play an important role, not only in the regulation of appetite, but also in the regulation of anxiety.
Copyright 2001 S. Karger AG, Basel
Similar articles
-
Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior.J Neurosci. 2002 Jan 1;22(1):193-9. doi: 10.1523/JNEUROSCI.22-01-00193.2002. J Neurosci. 2002. PMID: 11756502 Free PMC article.
-
Analysis of the stress response in rats trained in the water-maze: differential expression of corticotropin-releasing hormone, CRH-R1, glucocorticoid receptors and brain-derived neurotrophic factor in limbic regions.Neuroendocrinology. 2005;82(5-6):306-19. doi: 10.1159/000093129. Epub 2006 May 4. Neuroendocrinology. 2005. PMID: 16721035
-
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress.Nat Genet. 2000 Apr;24(4):410-4. doi: 10.1038/74263. Nat Genet. 2000. PMID: 10742108
-
An Integrative Review on Role and Mechanisms of Ghrelin in Stress, Anxiety and Depression.Curr Drug Targets. 2016;17(5):495-507. doi: 10.2174/1389450116666150518095650. Curr Drug Targets. 2016. PMID: 25981609 Review.
-
Hormonal pertubations in fibromyalgia syndrome.Ann N Y Acad Sci. 1999 Jun 22;876:325-38; discussion 339. doi: 10.1111/j.1749-6632.1999.tb07657.x. Ann N Y Acad Sci. 1999. PMID: 10415628 Review.
Cited by
-
Backstage of Eating Disorder-About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa.Nutrients. 2020 Aug 27;12(9):2604. doi: 10.3390/nu12092604. Nutrients. 2020. PMID: 32867089 Free PMC article. Review.
-
Role of SST, CORT and ghrelin and its receptors at the endocrine pancreas.Front Endocrinol (Lausanne). 2012 Sep 18;3:114. doi: 10.3389/fendo.2012.00114. eCollection 2012. Front Endocrinol (Lausanne). 2012. PMID: 23162532 Free PMC article.
-
The brain-adipocyte-gut network: Linking obesity and depression subtypes.Cogn Affect Behav Neurosci. 2018 Dec;18(6):1121-1144. doi: 10.3758/s13415-018-0626-0. Cogn Affect Behav Neurosci. 2018. PMID: 30112671 Review.
-
Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y.Ann N Y Acad Sci. 2019 Nov;1455(1):59-80. doi: 10.1111/nyas.14179. Epub 2019 Jul 4. Ann N Y Acad Sci. 2019. PMID: 31271235 Free PMC article. Review.
-
Neuroendocrine drivers of risk and resilience: The influence of metabolism & mitochondria.Front Neuroendocrinol. 2019 Jul;54:100770. doi: 10.1016/j.yfrne.2019.100770. Epub 2019 Jul 6. Front Neuroendocrinol. 2019. PMID: 31288042 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources