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. 1976;2(4):339-43.

Discriminable effects of benzodiazepines

D A Overton
  • PMID: 11529

Discriminable effects of benzodiazepines

D A Overton. Psychopharmacol Commun. 1976.

Abstract

In a shock-escape T-maze task, rats rapidly discriminated diazepam, flurazepam and chloridazepoxide from no drug. The discriminable effects of these benzodiazepines were not completely interchangeable with those of barbiturate anesthetics. The dose-response curve for diazepam asymptoted over the range 15 to 100 mg/kg, ip whereas dose-response curves for flurazepam and chloridazepoxide were more linear.

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