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Review
. 2001 Jul;74(1):18-25.
doi: 10.1007/BF02982545.

Transforming growth factor beta, pleiotropic regulator of hematopoietic stem cells: potential physiological and clinical relevance

F W Ruscetti  1 , S H Bartelmez
Affiliations
Review

Transforming growth factor beta, pleiotropic regulator of hematopoietic stem cells: potential physiological and clinical relevance

F W Ruscetti et al. Int J Hematol. 2001 Jul.

Abstract

Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodifferentiative or antidifferentiative. TGF-beta is the major regulator of stem cell quiescence and can act directly or indirectly through effects on the marrow microenvironment. In addition, paracrine and autocrine actions of TGF-beta have overlapping but distinct regulatory effects on hematopoietic stem/progenitor cells. Neutralization of autocrine TGF-beta has therapeutic potential.

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Comment in

  • Cytokines and hematology.
    Kasakura S. Kasakura S. Int J Hematol. 2001 Jul;74(1):1-2. doi: 10.1007/BF02982542. Int J Hematol. 2001. PMID: 11530797 No abstract available.

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