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. 2001:1:11.
doi: 10.1186/1471-2407-1-11. Epub 2001 Aug 10.

Digitoxin medication and cancer; case control and internal dose-response studies

J Haux  1 , O Klepp, O Spigset, S Tretli
Affiliations

Digitoxin medication and cancer; case control and internal dose-response studies

J Haux et al. BMC Cancer. 2001.

Abstract

Background: Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population.

Methods: Computer stored data on digitoxin concentrations in plasma from 9271 patients with cardiac disease were used to define a user population. Age and sex matched controls from the Norwegian Cancer Registry were used to calculate the number of expected cancer cases.

Results: The population on digitoxin showed a higher incidence of cancer compared to the control population. However, an additional analysis showed that the population on digitoxin had a general increased risk of cancer already, before the start on digitoxin. Leukemia/lymphoma were the cancer types which stood out with the highest risk in the digitoxin population before starting on digitoxin. This indicates that yet unknown risk factors exist for cardiovascular disease and lymphoproliferative cancer. An internal dose-response analysis revealed a relationship between high plasma concentration of digitoxin and a lower risk for leukemia/lymphoma and for cancer of the kidney/urinary tract.

Conclusion: Morbidity and mortality are high in the population on digitoxin, due to high age and cardiac disease. These factors disturb efforts to isolate an eventual anticancer effect of digitoxin in this setting. Still, the results may indicate an anticancer effect of digitoxin for leukemia/lymphoma and kidney/urinary tract cancers. Prospective clinical cancer trials have to be done to find out if digitoxin and other cardiac glycosides are useful as anticancer agents.

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References

    1. Westheim A, Dickstein K, Gundersen T, Hole T, Kjekshus J, Myhre ES, Ronnevik PK, Samstad S, Smith P. [Chronic heart failure – suggestion to a management program]. Tidsskr Nor Laegeforen. 1999;119:3427–3431. - PubMed
    1. Roever C, Ferrante J, Gonzalez EC, Pal N, Roetzheim RG. Comparing the toxicity of digoxin and digitoxin in a geriatric population: should an old drug be rediscovered? South Med J. 2000;93:199–202. - PubMed
    1. Shiratori O. Growth inhibitory effect of cardiac glycosides and agly cones on neoplastic cells: in vitro and in vivo studies. Gann. 1967;58:521–528. - PubMed
    1. Repke KRH. The role of the Na+/K+ pump in normal and cancer cell proliferation. Biomemebranes, Basic and Medical Research (Edited by Benga G, Tager JM) Berlin, Springer Verlag. 1988. pp. 161–176.
    1. Repke KR, Schon R, Megges R, Wetland J, Nissen E, Matthes E. Potential suitability of Na+/K(+)-transporting ATPase in pre-screens for anti-cancer agents. Anticancer Drug Des. 1995;10:177–87. - PubMed

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