A modified assay of total faecal bile acid excretion for clinical studies

Abstract

Faecal bile acid excretion was estimated in a clinical laboratory using gas liquid chromatography. The original method of Grundy et al was simplified so that quantitative thin layer chromatography was not required. Rigid dietary control or inpatient facilities were unnecessary for clinical studies. Control patients studied under these conditions had a daily faecal bile acid excretion of 0.37 +/- 0.13 g/day. Patients with ileal resections varied markedly with bile acid excretions ranging from 0.25--6.32 g/day (mean 2.36 +/- 1.11).