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Review
. 2001 Oct;11(5):554-60.
doi: 10.1016/s0959-437x(00)00232-x.

Notch signaling in lymphocyte development

A C Anderson  1 , E A Robey, Y H Huang
Affiliations
Review

Notch signaling in lymphocyte development

A C Anderson et al. Curr Opin Genet Dev. 2001 Oct.

Abstract

Signaling through Notch has been implicated in many cell-fate decisions during lymphocyte development. Recent studies have provided new clues--and raised new controversies--regarding the exact role that Notch signaling plays in the commitment of cells to the T-cell lineage. Progress has also been made in deducing the transcriptional program induced by Notch and the mechanism of oncogenic transformation by Notch in lymphocytes.

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