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Review
. 2001 Sep 1:6:D1065-8.
doi: 10.2741/A668.

Bromodomain motifs and "scaffolding"?

G V Denis  1
Affiliations
Review

Bromodomain motifs and "scaffolding"?

G V Denis. Front Biosci. .

Abstract

Bromodomain-containing multiprotein complexes share some of the properties of signal transduction scaffolds. Insights from MAP kinase signaling scaffolds, for example, may provide useful perspectives for future studies of bromodomain proteins. The regulatory processes of modification (phosphorylation, acetylation, ubiquitination), turnover, nuclear compartmentalization, feedback regulation and signaling pathway specificity are all likely to contribute to the mechanisms by which bromodomain-containing multiprotein complexes control transcription.

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