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. 2001 Aug 15;10(17):1847-51.
doi: 10.1093/hmg/10.17.1847.

alpha-Synuclein gene haplotypes are associated with Parkinson's disease

M Farrer  1 , D M Maraganore, P Lockhart, A Singleton, T G Lesnick, M de Andrade, A West, R de Silva, J Hardy, D Hernandez
Affiliations

alpha-Synuclein gene haplotypes are associated with Parkinson's disease

M Farrer et al. Hum Mol Genet. .

Abstract

We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.

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