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Clinical Trial
. 2001 Jul;18(7):364-8.

[Low molecular weight heparin versus unfractionated heparin in the treatment of deep vein thrombosis]

[Article in Spanish]
J J Moreno-Palomares  1 , R M Fisac-Herrero, A Herrero-Domingo, E M Ferreira-Pasos, J Grasa, D Reverte-Cejudo
Affiliations
  • PMID: 11534421
Clinical Trial

[Low molecular weight heparin versus unfractionated heparin in the treatment of deep vein thrombosis]

[Article in Spanish]
J J Moreno-Palomares et al. An Med Interna. 2001 Jul.

Abstract

Background: Low-molecular-weight heparin (LMWH) are replacing unfractionated heparin (UH) in treatment of deep vein thrombosis (DVP), showing their security and effectiveness.

Methods: To demonstrate their security and effectiveness a randomized prospective study was realised. It compared UH with LMWH in DP treatment, clinically diagnosed and confirmed with eco-Doppler. The study included 32 patients (21 males and 11 females); 15 received UH in continuos i.v. infusion and 17 sodic dalteparine, with dicumarinic afterwards in every case. The patients were followed for one year.

Results: There were no differences between the two groups of treatment in clinical/radiological effectiveness either in short term nor one year follow up. There were no significative differences in side effects.

Conclusion: LMWH are as effective and safe as UH for DVT treatment. They also have a more comfortable dosage for the patient, avoiding the i.v. infusion and the coagulation test, which allows treatment at home.

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