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Review
. 2001 Sep 3;154(5):909-11.
doi: 10.1083/jcb.200108010.

A new view of the spindle checkpoint

M A Hoyt  1
Affiliations
Review

A new view of the spindle checkpoint

M A Hoyt. J Cell Biol. .

Abstract

Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.

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References

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