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. 1989;8(3):407-14.
doi: 10.1080/07328318908054184.

N-cyanoimidazole and diimidazole imine: water-soluble condensing agents for the formation of the phosphodiester bond

J P Ferris  1 , C H Huang, W J Hagan Jr
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N-cyanoimidazole and diimidazole imine: water-soluble condensing agents for the formation of the phosphodiester bond

J P Ferris et al. Nucleosides Nucleotides. 1989.

Abstract

The reaction of BrCN with imidazole results in the formation of N-cyanoimidazole and diimidazole imine. These compounds were shown to be useful condensing agents for the formation of the phosphodiester bound in aqueous solution.

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