doi: 10.1021/ja990440u.
Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization
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- PMID: 11542282
- DOI: 10.1021/ja990440u
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Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization
J Am Chem Soc.
1999.
Abstract
Hexitol nucleic acids (HNAs) are DNA analogues that contain the standard nucleoside bases attached to a phosphorylated 1,5-anhydrohexitol backbone. We find that HNAs support efficient information transfer in nonensymatic template-directed reactions. HNA heterosequences appeared to be superior to the corresponding DNA heterosequences in facilitating synthesis of complementary oligonucleotides from nucleoside-5'-phosphoro-2-methyl imidazolides.
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