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Review
. 2001 Oct;13(5):549-54.
doi: 10.1016/s0952-7915(00)00257-0.

The role of cytotoxicity in lymphocyte homeostasis

G de Saint Basile  1 , A Fischer
Affiliations
Review

The role of cytotoxicity in lymphocyte homeostasis

G de Saint Basile et al. Curr Opin Immunol. 2001 Oct.

Abstract

Several human inherited immune disorders lead to the same fatal lymphoproliferative syndrome, called the hemophagocytic syndrome. Through defective perforin expression or transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in the regulation of the immune response and in lymphocyte homeostasis. In addition, new effectors of this secretory pathway have been identified.

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