Review
doi: 10.1016/s0955-0674(00)00251-9.
Anoikis mechanisms
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- PMID: 11544023
- DOI: 10.1016/s0955-0674(00)00251-9
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Review
Anoikis mechanisms
Curr Opin Cell Biol.
2001 Oct.
Abstract
Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.
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