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Review
. 2001 Sep;108(5):649-54.
doi: 10.1172/JCI13903.

Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouse's tale

N Platt  1 , S Gordon
Affiliations
Review

Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouse's tale

N Platt et al. J Clin Invest. 2001 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Structures of the class A macrophage SR. (a) Domain organization of type I and type II receptors. Extended (b) and compact (c) forms of soluble receptor have been seen by rotary shadowing and negative staining (8). Adapted, with modifications from refs. and (3).
Figure 2
Figure 2
Putative biological roles for SR-A. In vitro studies that have examined the breadth of SR-A activities, together with analyses of the SR-A–deficient mouse, have suggested a number of different biological roles for the receptor. These include the endocytosis of modified lipoproteins and its association with vascular disease; the adhesion of Mφ to the substratum and other populations of cells; the binding and ingestion of microbes; the detoxification of pathogen-specific components; and the phagocytosis of apoptotic or unwanted host cells.
See this image and copyright information in PMC

References

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