Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2001:106 Suppl 2:229-32.

Molecular characterization of hereditary persistence of foetal haemoglobin mutation by restriction fragment length polymorphism mapping

S K Das  1 , M De, D K Bhattacharya, G Talukder
Affiliations
  • PMID: 11545449
Case Reports

Molecular characterization of hereditary persistence of foetal haemoglobin mutation by restriction fragment length polymorphism mapping

S K Das et al. Cytobios. 2001.

Abstract

Characterization of hereditary persistence of foetal haemoglobin (HPFH) mutation in a family from West Bengal, India, was carried out by analysing the structure of the 5'-Ggamma-Agamma-psibeta-delta-beta-3' globin gene region by using the restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique. The HPFH in this family was due to a deletion in the beta-globin gene cluster spanning at least from the Hin cII/5' psibeta to the Hin fI/3' beta RFLP site. This work indicates the importance of RFLP-PCR technique in characterization of the HPFH mutation.

PubMed Disclaimer

Publication types