Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Sep 7;293(5536):1840-2.
doi: 10.1126/science.1062882.

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

M Hatta  1 , P Gao, P Halfmann, Y Kawaoka
Affiliations

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

M Hatta et al. Science. .

Abstract

In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.

PubMed Disclaimer

Comment in

  • Virology. A molecular whodunit.
    Webster RG. Webster RG. Science. 2001 Sep 7;293(5536):1773-5. doi: 10.1126/science.1065206. Science. 2001. PMID: 11546856 No abstract available.

Publication types

MeSH terms

Substances

LinkOut - more resources