doi: 10.1126/science.1062882.
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
Affiliations
- PMID: 11546875
- DOI: 10.1126/science.1062882
Item in Clipboard
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
Science.
.
Abstract
In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.
Comment in
-
Virology. A molecular whodunit.Science. 2001 Sep 7;293(5536):1773-5. doi: 10.1126/science.1065206. Science. 2001. PMID: 11546856 No abstract available.
Similar articles
-
The genesis of a pandemic influenza virus.Cell. 2005 Nov 4;123(3):368-71. doi: 10.1016/j.cell.2005.10.019. Cell. 2005. PMID: 16269328
-
PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice.Virology. 2004 Mar 15;320(2):258-66. doi: 10.1016/j.virol.2003.11.030. Virology. 2004. PMID: 15016548
-
Reverse genetics approach towards understanding pathogenesis of H5N1 Hong Kong influenza A virus infection.Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1841-3. doi: 10.1098/rstb.2001.1000. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11779382 Free PMC article. Review.
-
Virology. Clues to the virulence of H5N1 viruses in humans.Science. 2006 Mar 17;311(5767):1562-3. doi: 10.1126/science.1125998. Science. 2006. PMID: 16543447 No abstract available.
-
[Influenza A(H5N1) in Hong Kong: forerunner of a pandemic or an only scientifically interesting phenomenon and a useful exercise in pandemiology?].Tijdschr Diergeneeskd. 1998 May 1;123(9):278-82. Tijdschr Diergeneeskd. 1998. PMID: 9602508 Review. Dutch.
Cited by
-
Organization of the influenza virus replication machinery.Science. 2012 Dec 21;338(6114):1631-4. doi: 10.1126/science.1227270. Epub 2012 Nov 22. Science. 2012. PMID: 23180774 Free PMC article.
-
Human infection from avian-like influenza A (H1N1) viruses in pigs, China.Emerg Infect Dis. 2012 Jul;18(7):1144-6. doi: 10.3201/eid1807.120009. Emerg Infect Dis. 2012. PMID: 22709385 Free PMC article.
-
Vaccination and Antiviral Treatment against Avian Influenza H5Nx Viruses: A Harbinger of Virus Control or Evolution.Vaccines (Basel). 2023 Oct 24;11(11):1628. doi: 10.3390/vaccines11111628. Vaccines (Basel). 2023. PMID: 38005960 Free PMC article. Review.
-
A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity and neurovirulence of H5N1 influenza virus in mice.J Virol. 2012 Jun;86(12):6924-31. doi: 10.1128/JVI.07142-11. Epub 2012 Apr 11. J Virol. 2012. PMID: 22496231 Free PMC article.
-
Human-like PB2 627K influenza virus polymerase activity is regulated by importin-α1 and -α7.PLoS Pathog. 2012 Jan;8(1):e1002488. doi: 10.1371/journal.ppat.1002488. Epub 2012 Jan 19. PLoS Pathog. 2012. PMID: 22275867 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
