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. 2001 Sep 17;11(18):2555-9.
doi: 10.1016/s0960-894x(01)00497-8.

New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives

I Robina  1 , A J Moreno-Vargas, J G Fernández-Bolaños, J Fuentes, R Demange, P Vogel
Affiliations

New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives

I Robina et al. Bioorg Med Chem Lett. .

Abstract

Readily derived from D-glucose, 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoic esters and amides are selective and competitive inhibitors (K(i)> or = 3 microM) of alpha-L-fucosidase from bovine epididymis and from human placenta.

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