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. 1975 Apr;83(2):100-2.
doi: 10.1111/j.1699-0463.1975.tb00077.x.

Influence of therapeutic concentrations of phenylbutazone on granulocyte function

C O Solberg

Influence of therapeutic concentrations of phenylbutazone on granulocyte function

C O Solberg. Acta Pathol Microbiol Scand B. 1975 Apr.

Abstract

The influence of therapeutic concentrations of phenylbutazone on human granulocyte function has been examined using a method which facilitates a precise in vitro evaluation of the phagocytic and bactericidal activities of polymorphonuclear leucocytes. Phenylbutazone caused a marked reduction in intracellular killing of bacteria by the granulocytes. Whether this inhibition of granulocyte function also takes place in vivo resulting in enhanced susceptibility to infection, remains unknown.

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