Review
doi: 10.1016/s0958-1669(00)00225-1.
Mapping protein-protein interactions with combinatorial biology methods
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- PMID: 11551461
- DOI: 10.1016/s0958-1669(00)00225-1
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Review
Mapping protein-protein interactions with combinatorial biology methods
Curr Opin Biotechnol.
2001 Aug.
Abstract
Extremely diverse, DNA-encoded libraries of peptides and proteins have been constructed that include a linkage between each polypeptide and the encoding DNA. Library members can be selected by virtue of a particular binding specificity, and their protein sequence can be deduced from the sequence of the cognate DNA. Such combinatorial biology methods have proven invaluable in both identifying natural protein-protein interactions and also in mapping the specificities and energetics of these interactions in fine detail.
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