Review
doi: 10.1016/s1043-2760(01)00454-4.
CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor
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- PMID: 11551811
- DOI: 10.1016/s1043-2760(01)00454-4
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Review
CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor
Trends Endocrinol Metab.
2001 Oct.
Abstract
Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO(3)(-)). As the concentration of HCO(3)(-) reflects cellular levels of carbon dioxide (CO(2)), energy-generating metabolic processes (which increase intracellular CO(2)) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation.
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