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Case Reports
. 2001 Aug;42(8):1084-6.
doi: 10.1046/j.1528-1157.2001.0420081084.x.

Epileptic seizures after treatment with thiocolchicoside

P L De Riu  1 , G Rosati, S Sotgiu, G Sechi
Affiliations
Case Reports

Epileptic seizures after treatment with thiocolchicoside

P L De Riu et al. Epilepsia. 2001 Aug.

Abstract

Purpose: To report the occurrence of epileptic seizures in humans, closely related to the use of the centrally acting muscle relaxant thiocolchicoside.

Methods: Description of three case histories.

Results: Two patients, affected with complex-partial seizures, sometimes secondarily generalized, receiving antiepileptic therapy, were seizure free for 7 and 9 years, respectively. They had the reappearance of tonic-clonic seizures few days after the continued use of thiocolchicoside, at a cumulative dose of the drug of 52 mg and 76 mg, respectively. The third patient was brain damaged and without a history of seizures. He had a sudden, convulsive seizure a few minutes after 4 mg intramuscular thiocolchicoside.

Conclusions: Our case histories indicate that thiocolchicoside has a powerful epileptogenic activity. This drug should be avoided in patients with epilepsy or acute brain injury and possible disruption of the blood-brain barrier.

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