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. 2001 Aug;6(8):624-34.
doi: 10.1046/j.1365-3156.2001.00757.x.

A longitudinal study of Giardia lamblia infection in north-east Brazilian children

R D Newman  1 , S R Moore, A A Lima, J P Nataro, R L Guerrant, C L Sears
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Free article

A longitudinal study of Giardia lamblia infection in north-east Brazilian children

R D Newman et al. Trop Med Int Health. 2001 Aug.
Free article

Abstract

Objective: To evaluate the epidemiology of Giardia lamblia infection, investigate factors which might be associated with clinical manifestations and recurrence, and examine the role of copathogens in disease course.

Methods: Prospective 4-year cohort study of children born in an urban slum in north-eastern Brazil.

Results: Of 157 children followed for > or = 3 months, 43 (27.4%) were infected with Giardia. The organism was identified in 8.8% of all stool specimens, and although found with similar frequency in non-diarrhoeal (7.4%) and diarrhoeal stools (9.7%), was more common in children with persistent (20.6%) than acute diarrhoea (7.6%, P=0.002). Recurrent or relapsing infections were common (46%). Children with symptomatic infections had significantly lower weight-for-age and height-for-age than asymptomatic children. Copathogens were not associated with disease course. CONCLUSION With its protean clinical manifestations, Giardia may be associated with substantial morbidity amongst children in Brazil.

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