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. 2001 Oct;9(10):2643-52.
doi: 10.1016/s0968-0896(01)00184-5.

Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones

R Kumar  1 , A Azim, V Kumar, S K Sharma, A K Prasad, O W Howarth, C E Olsen, S C Jain, V S Parmar
Affiliations

Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones

R Kumar et al. Bioorg Med Chem. 2001 Oct.

Abstract

The chemo- and enantioselective capabilities of porcine pancreatic lipase (PPL) in tetrahydrofuran, and Candida rugosa lipase (CRL) in diisopropyl ether have been investigated for the acetylation of racemic 2-alkyl/aryl-3-hydroxypropiophenones, which are important precursors in the synthesis of biologically active chromanones and isoflavanones. A highly chemoselective acetylation of primary hydroxy group in preference to phenolic hydroxy group leading to the formation of enantiomerically enriched monoacetates has been observed.

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