Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Oct;45(10):2897-901.
doi: 10.1128/AAC.45.10.2897-2901.2001.

Antimalarial drugs clear resistant parasites from partially immune hosts

P Cravo  1 , R Culleton, P Hunt, D Walliker, M J Mackinnon
Affiliations

Antimalarial drugs clear resistant parasites from partially immune hosts

P Cravo et al. Antimicrob Agents Chemother. 2001 Oct.

Abstract

Circumstantial evidence in human malaria suggests that elimination of parasites by drug treatment meets higher success rates in individuals having some background immunity. In this study, using the rodent malaria model Plasmodium chabaudi, we show that drug-resistant parasites can be cleared by drugs when the host is partially immune.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Results of experiments of P. chabaudi infections with resistant parasites (R) or sensitive parasites (S) in naïve and immunized mice following treatment (Treated) or no treatment (Untreated) with chloroquine. Numbers 1 to 8 represent the experimental groups shown in Table 2. (A) Parasitemias (log10 transformed) from days 5 to 21 postinfection. (B) Total parasitemias (log10 transformed) integrated over days 0 to 12 postinfection.
FIG. 2
FIG. 2
Results of experiments of P. chabaudi infections as for Fig. 1, except that the drug used was mefloquine.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Awasthi A, Mehrotra S, Bhakuni V, Dutta G P, Levy H B, Maheshwari R K. Poly ICLC enhances the antimalarial activity of chloroquine against multidrug-resistant Plasmodium yoelii nigeriensis in mice. J Interferon Cytokine Res. 1997;17:419–423. - PubMed
    1. Ballou W R, Kester K E, Stoute J A, Heppner D G. Malaria vaccines: triumphs or tribulations? Parassitologia. 1999;41:403–408. - PubMed
    1. Beale G H, Carter R, Walliker D. Genetics. In: Killick-Kendrick R, Peters W, editors. Rodent malaria. London, United Kingdom: Academic Press; 1978. pp. 213–245.
    1. Bjorkman A. Interactions between chemotherapy and immunity to malaria. Prog Allergy. 1988;41:331–356. - PubMed
    1. Brown G V. Progress in the development of malaria vaccines: context and constraints. Parassitologia. 1999;41:429–432. - PubMed

Publication types