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Comment
. 2001 Sep 14;293(5537):2012-3.
doi: 10.1126/science.1065591.

Immunology. Long live the mature B cell--a baffling mystery resolved

T J Waldschmidt  1 , R J Noelle
Affiliations
Comment

Immunology. Long live the mature B cell--a baffling mystery resolved

T J Waldschmidt et al. Science. .

Abstract

What determines whether transitional B cells newly emerged from the bone marrow will differentiate further to become mature, long-lived, circulating B lymphocytes? In a Perspective, Waldschmidt and Noelle discuss new findings showing that the TNF family ligand BAFF and its receptor BAFF-R are crucial for selecting transitional B cells into the mature B cell pool (Thompson et al., Schiemann et al.).

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