Antiinflammatory activity of alpha-methyl-3-phenyl-7-benzofuranacetic acid (R-803)
- PMID: 1156032
Item in Clipboard
Antiinflammatory activity of alpha-methyl-3-phenyl-7-benzofuranacetic acid (R-803)
Arch Int Pharmacodyn Ther.
1975 Apr.
Abstract
The antiinflammatory activity of R-803 (alpha-methyl-3-phenyl-7-benzofuranacetic acid), a new nonsteroidal drug, has been demonstrated. The oral administration of R-803 inhibits carrageenan-induced edema of the rat's paw, ultraviolet-induced erythema of guinea-pig skin, adjuvant-induced and 6-sulfonamidoindazole-induced arthritides of the rat at doses in the range of 1.0 to 6.0 mg/kg. It also inhibits the cotton pellet-induced granuloma in the rat at higher doses.
Similar articles
-
Pharmacological studies of Bufexamac topically applied on the skin.Arch Int Pharmacodyn Ther. 1970 Oct;187(2):401-14. Arch Int Pharmacodyn Ther. 1970. PMID: 5481488 No abstract available.
-
4-nitro-2-phenoxymethanesulfonanilide (R-805): a chemically novel anti-inflammatory agent.Arch Int Pharmacodyn Ther. 1976 May;221(1):132-9. Arch Int Pharmacodyn Ther. 1976. PMID: 962423
-
Assessment of topical non-steroidal anti-inflammatory drugs in animal models.Arzneimittelforschung. 1990 Oct;40(10):1117-24. Arzneimittelforschung. 1990. PMID: 2291749
-
[Pharmacologic properties of a new, nonsteroidal anti-inflammatory agent, bucloxic acid (804 CB)].Arzneimittelforschung. 1974 Sep;24(9A SUPPL):1368-78. Arzneimittelforschung. 1974. PMID: 4480066 French. No abstract available.
-
Anti-inflammatory and related properties of 4-(p-biphenylyl)-3-hydroxybutyric acid.Br J Pharmacol Chemother. 1968 Jun;33(2):396-407. doi: 10.1111/j.1476-5381.1968.tb01000.x. Br J Pharmacol Chemother. 1968. PMID: 5664158 Free PMC article. No abstract available.
Cited by
-
The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs.Agents Actions. 1977 Dec;7(5-6):573-7. doi: 10.1007/BF02111132. Agents Actions. 1977. PMID: 602882