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Review
. 2001 Sep;108(6):793-7.
doi: 10.1172/JCI14011.

Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems

M Krieger  1
Affiliations
Review

Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems

M Krieger. J Clin Invest. 2001 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Model of the topology of SR-BI. SR-BI is a 509-residue glycoprotein with a large extracellular loop (∼403 residues) anchored to the plasma membrane at both the N- and C-termini by transmembrane domains (∼28 and ∼25 residues) which have short extensions into the cytoplasm (∼8 N-terminal residues and ∼45 C-terminal residues). The approximate locations of the cysteines are shown (“C”). The protein is heavily N-glycosylated, and it is palmitoylated on the cysteines in the C-terminal cytoplasmic and transmembrane domains, Cys462 and Cys470 (murine numbering system). Adapted from ref. .
Figure 2
Figure 2
Role of SR-BI in HDL metabolism in vivo. HDL is thought to extract cellular cholesterol from peripheral tissues by a mechanism involving the product of the ABCA1 (Tangier disease) gene. After the plasma HDL-cholesterol (HDL-C) is esterified to cholesteryl ester (CE) by the enzyme lipoprotein lipase (not shown), it can be transported to the liver by either an indirect pathway (transfer to other lipoproteins followed by hepatic receptor-mediated endocytosis, not shown) or a direct pathway via SR-BI and selective cholesterol uptake. The HDL-C in the liver can be secreted into the bile, either as cholesterol or as bile acids. The delivery of cholesterol from peripheral tissues via plasma HDL to the liver for biliary excretion as cholesterol or bile acids is called “reverse cholesterol transport.” SR-BI also can mediate HDL-C uptake by steroidogenic tissues for steroid hormone synthesis or cholesterol storage. Redrawn from refs. , .
See this image and copyright information in PMC

References

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