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Review
. 2001 Sep 17;194(6):F37-42.
doi: 10.1084/jem.194.6.f37.

Lymphatic vessels as targets of tumor therapy?

T Karpanen  1 , K Alitalo
Affiliations
Review

Lymphatic vessels as targets of tumor therapy?

T Karpanen et al. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
Tumor lymphangiogenesis and its inhibition. VEGF-C and VEGF-D produced by tumor cells or associated inflammatory cells induce the growth of lymphatic vessels in the tumor periphery. These factors may also contribute to angiogenesis induced by VEGF. Tumor cells grow inside of the lymphatic vessels, which provide a route for tumor metastasis. Shown in the top part are various approaches to inhibit tumor lymphangiogenesis and lymphatic metastasis by blocking VEGFR-3 signaling.
Figure 2
Figure 2
Inhibition of tumor lymphangiogenesis by adenovirally encoded soluble VEGFR-3. MCF-7 breast carcinoma cells were stably transfected with a VEGF-C expression plasmid (A and B) or an empty vector (C) and 107 cells were injected into the mammary fad pads of ovariectomized SCID mice carrying slow-release estrogen pellets. The mice were injected intravenously with 109 PFU of an adenovirus encoding soluble VEGFR-3 (B) or control adenovirus (A and C). See reference 4 for further details.
See this image and copyright information in PMC

Comment on

References

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