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. 2001 Apr-Jul;20(4-7):1389-92.
doi: 10.1081/NCN-100002562.

Preparation of 3'-C-branched uridine analogues, suitable for conversion into functionalised 3'-C-methylene derivatives

A Winqvist  1 , R Strömberg
Affiliations

Preparation of 3'-C-branched uridine analogues, suitable for conversion into functionalised 3'-C-methylene derivatives

A Winqvist et al. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul.

Abstract

A novel method for preparation of 1-[2-O-(tert-butyldimethylsilyl)-3- deoxy-3-C-hydroxymethyl-5-O-monomethoxytrityl-beta-D-ribo- pentofuranosyl]uracil by hydroboration of corresponding 3'-deoxy-3'-C-methyleneuridine derivative has been developed. Further conversion of the hydroxyl function into different leaving groups was carried out to afford derivatives suitable for conversion into various 3'-C-branched uridine analogues through substitution.

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