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Review
. 2001 Apr-Jul;20(4-7):451-9.
doi: 10.1081/NCN-100002319.

Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites

V E Marquez  1 , P Wang, M C Nicklaus, M Maier, M Manoharan, J K Christman, N K Banavali, A D Mackerell Jr
Affiliations
Review

Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites

V E Marquez et al. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul.

Abstract

Pseudorotationally locked sugar analogues based on bicyclo[3.1.0]-hexane templates were placed in DNA duplexes as abasic target sites in the M. HhaI recognition sequence. The binding affinity of the enzyme increases when the abasic site is constrained to the South conformation and decreases when it is constrained to the North conformation. A structural understanding of these differences is provided.

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