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Review
. 2001 Sep;3(11):891-8.
doi: 10.1016/s1286-4579(01)01449-6.

Role of IL-10 in allergen-specific immunotherapy and normal response to allergens

C A Akdis  1 , K Blaser
Affiliations
Free article
Review

Role of IL-10 in allergen-specific immunotherapy and normal response to allergens

C A Akdis et al. Microbes Infect. 2001 Sep.
Free article

Abstract

Induction of specific unresponsiveness (tolerance/anergy) in peripheral T cells by interleukin-10 (IL-10) and recovery by cytokines from the tissue microenvironment represent two key steps in specific immunotherapy of allergy and in natural exposure to allergens in healthy individuals. IL-10 elicits anergy in T cells by selective inhibition of the CD28 costimulatory pathway and controls suppression and development of antigen-specific immunity.

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