Review
doi: 10.1016/s1286-4579(01)01453-8.
Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells
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- PMID: 11564440
- DOI: 10.1016/s1286-4579(01)01453-8
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Review
Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells
Microbes Infect.
2001 Sep.
Free article
Abstract
CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25(-) effectors by a T-T interaction.
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