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Review
. 2001 Sep;3(11):919-27.
doi: 10.1016/s1286-4579(01)01453-8.

Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells

R S McHugh  1 , E M Shevach, A M Thornton
Affiliations
Free article
Review

Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells

R S McHugh et al. Microbes Infect. 2001 Sep.
Free article

Abstract

CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25(-) effectors by a T-T interaction.

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