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Review
. 2001 Sep-Oct;18(5):347-51.
doi: 10.1177/104990910101800511.

Thalidomide: dual benefits in palliative medicine and oncology

M P Davis  1 , E D Dickerson
Affiliations
Review

Thalidomide: dual benefits in palliative medicine and oncology

M P Davis et al. Am J Hosp Palliat Care. 2001 Sep-Oct.

Abstract

Thalidomide is an immunomodulator, anti-angiogenic agent, anti-cytokine, and anti-integrin. Alone or in combination with other drugs, thalidomide has also demonstrated anti-cachexin and anti-neoplastic properties. Anorexia and cachexia are common symptoms of advanced cancer. Since certain cytokines also promote tumor growth, we may have a class of agents with palliative and anti-tumor benefits in combination with anti-neoplastics and anti-cytokines, such as thalidomide.

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