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. 2001 Sep 15;358(9285):889-90.
doi: 10.1016/S0140-6736(01)06039-1.

Uptake of screening and prevention in women at very high risk of breast cancer

D Evans, F Lalloo, A Shenton, C Boggis, A Howell

Uptake of screening and prevention in women at very high risk of breast cancer

D Evans et al. Lancet. .

Abstract

Management of women at high lifetime risk of familial breast cancer is hampered because of limited data concerning the appropriateness of treatment options. Over the past 8 years women at very high (>40%) lifetime risk of breast cancer have had the option of entering two chemoprevention treatment trials, a magnetic resonance imaging (MRI) breast screening study, or a risk-reducing mastectomy (RRM) study. Only 10% of eligible women have entered one of the chemotherapy trials with a similar proportion opting for RRM (>50% in mutation carriers) compared with 60% opting for MRI screening. Future chemotherapy trials will have to be designed to address this poor recruitment.

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Comment in

  • Recruitment of women into trials.
    Benson JR. Benson JR. Lancet. 2002 Jan 12;359(9301):164. doi: 10.1016/s0140-6736(02)07341-5. Lancet. 2002. PMID: 11809281 No abstract available.
  • Recruitment of women into trials.
    Bartlett EE. Bartlett EE. Lancet. 2002 Jan 12;359(9301):165. doi: 10.1016/S0140-6736(02)07343-9. Lancet. 2002. PMID: 11809282 No abstract available.
  • Recruitment of women into trials.
    Smyth A, Hyman-Taylor P, Lewis S, Knox A, Stephenson T. Smyth A, et al. Lancet. 2002 Jan 12;359(9301):165-6. doi: 10.1016/S0140-6736(02)07344-0. Lancet. 2002. PMID: 11809283 No abstract available.
  • Recruitment of women into trials.
    Thornton H, Dixon-Woods M. Thornton H, et al. Lancet. 2002 Jan 12;359(9301):164-5. doi: 10.1016/S0140-6736(02)07342-7. Lancet. 2002. PMID: 11809284 No abstract available.

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