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Comparative Study
. 2001 Aug;86(4):451-3.
doi: 10.1254/jjp.86.451.

Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT

S Isayama  1 , Y Sugimoto, M Nishiga, C Kamei
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Free article
Comparative Study

Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT

S Isayama et al. Jpn J Pharmacol. 2001 Aug.
Free article

Abstract

We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

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