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Review
. 2001 Oct:16:197-200.
doi: 10.1152/physiologyonline.2001.16.5.197.

Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells

A Spät  1 , J G Pitter, T Rohács, G Szabadkai
Affiliations
Review

Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells

A Spät et al. News Physiol Sci. 2001 Oct.

Abstract

Ca(2+) signal in high-Ca(2+) perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca(2+)-dependent dehydrogenases. In steroid-secreting cells, small cytoplasmic Ca(2+) signals may also augment mitochondrial Ca(2+) concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.

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