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Review
. 2001 Oct:16:214-7.
doi: 10.1152/physiologyonline.2001.16.5.214.

ATP-sensitive potassium channels in dopaminergic neurons: transducers of mitochondrial dysfunction

B Liss  1 , J Roeper
Affiliations
Review

ATP-sensitive potassium channels in dopaminergic neurons: transducers of mitochondrial dysfunction

B Liss et al. News Physiol Sci. 2001 Oct.

Abstract

ATP-sensitive potassium (K(ATP)) channels directly couple the metabolic state of a cell to its electrical activity. Dopaminergic midbrain neurons express alternative types of K(ATP) channels mediating their differential response to mitochondrial complex I inhibition. Because reduced complex I activity is present in Parkinson's Disease, differential K(ATP) channel expression suggests a novel candidate mechanism for selective dopaminergic degeneration.

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