Antidepressant trials generally have methodological defects
- PMID: 11573492
- PMCID: PMC1121146
- DOI: 10.1136/bmj.323.7312.574
Antidepressant trials generally have methodological defects
Comment on
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Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.BMJ. 2000 Sep 2;321(7260):536-9. doi: 10.1136/bmj.321.7260.536. BMJ. 2000. PMID: 10968813 Free PMC article. Clinical Trial.
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Comparison of St John's Wort and imipramine. Remission is important outcome.BMJ. 2001 Feb 24;322(7284):493; author reply 494. BMJ. 2001. PMID: 11222430 Free PMC article. No abstract available.
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Comparison of St John's Wort and imipramine. Study design casts doubt on value of St John's wort in treating depression.BMJ. 2001 Feb 24;322(7284):493; author reply 494. BMJ. 2001. PMID: 11222432 No abstract available.
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Comparison of St John's Wort and imipramine. Finding must be treated with caution.BMJ. 2001 Feb 24;322(7284):493; author reply 494. BMJ. 2001. PMID: 11222434 No abstract available.
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Comparison of St John's Wort and imipramine. Sensitivity of assay is questionable.BMJ. 2001 Feb 24;322(7284):493-4. BMJ. 2001. PMID: 11256367 No abstract available.
References
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- Even C, Siobud-Dorocant E, Dardennes RM. Critical approach to antidepressant trials. Blindness protection is necessary, feasible and measurable. Br J Psychiatry. 2000;177:47–51. - PubMed
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