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. 2001 Oct;60(4):1592-7.
doi: 10.1046/j.1523-1755.2001.00973.x.

Physiological aspects of pig-to-primate renal xenotransplantation

B Soin  1 , K G Smith, A Zaidi, E Cozzi, J R Bradley, D J Ostlie, A Lockhart, D J White, P J Friend
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Free article

Physiological aspects of pig-to-primate renal xenotransplantation

B Soin et al. Kidney Int. 2001 Oct.
Free article

Abstract

Background: Few data exist on the physiological aspects of pig-to-primate renal xenotransplantation.

Methods: Use of organs transgenic for human decay accelerating factor has allowed assessment of the metabolic and hormonal functions of these xenografts.

Results: Porcine renal xenografts largely maintain plasma electrolyte homeostasis. An increase in proteinuria was detected that may result from graft injury. In contrast to allotransplantation a severe anaemia developed requiring recipient treatment with exogenous human erythropoietin.

Conclusions: Our experience provides qualified encouragement for the likely physiological compatibility of pig and primate species, but identifies areas where a xenograft may not match the performance of an allograft.

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