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Review
. 2001 Oct;54(5):285-8.
doi: 10.1136/mp.54.5.285.

IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

W Zumkeller  1
Affiliations
Review

IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

W Zumkeller. Mol Pathol. 2001 Oct.

Abstract

Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysregulation of the IGF system is a frequent pattern in malignancy, IGFs/IGFBPs might represent novel tumour markers that could be useful both for diagnosis and surveillance.

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