[Levofolinate and fluorouracil combination therapy]
- PMID: 11577462
- DOI: 10.1254/fpj.118.211
[Levofolinate and fluorouracil combination therapy]
Abstract
Levofolinate and fluorouracil regimen (l-leucovorin and 5 fluorouracil regimen) is a biochemical modulation of 5 fluorouracil (5FU) by leucovorin (LV). In the USA and Europe d,l-LV and 5FU regimen is frequently administered for colorectal cancer treatment and recognized as the standard regimen. In Japan, multi-institutional clinical trials of l-leucovorin (l-LV), a bioactive diastereomer of leucovorin, and 5FU combination were conducted for the treatment of advanced gastrointestinal cancer with comparable results to the US/Europe data. This l-LV and 5FU regimen was approved in August 1999 for the indications of advanced gastric cancer and colorectal cancer. The dosage and administration is referred to the weekly method developed at RPMI. Recently, the irinotecan (CPT-11) or oxariplatin plus LV and 5FU combination showed higher antitumor activities than the LV and 5FU combination with increased progression-free survival. These regimens, however, are not yet properly established because clinical trial results with Japanese patients are not completed for agreement of the dosage and administration schedule. For the l-LV and 5FU regimen diarrhea and leukocytopenia, including grade 3 and higher, were reported as the major adverse events. Administration for eligible patients with periodical monitoring of diagnostic data is necessary.
Similar articles
-
A prospective randomized study of irinotecan (CPT-11), leucovorin (LV) and 5-fluorouracil (5FU) versus leucovorin and 5-fluorouracil in patients with advanced colorectal carcinoma.J Chemother. 2006 Oct;18(5):538-44. doi: 10.1179/joc.2006.18.5.538. J Chemother. 2006. PMID: 17127232 Clinical Trial.
-
Efficacy and safety of an irinotecan plus bolus 5-fluorouracil and L-leucovorin regimen for metastatic colorectal cancer in Japanese patients: experience in a single institution in Japan.Jpn J Clin Oncol. 2007 Sep;37(9):686-91. doi: 10.1093/jjco/hym091. Epub 2007 Aug 24. Jpn J Clin Oncol. 2007. PMID: 17720736
-
Clinical impact of adjuvant chemotherapy on patients with stage III colorectal cancer: l-LV/5FU chemotherapy as a modified RPMI regimen is an independent prognostic factor for survival.Anticancer Res. 2006 Mar-Apr;26(2B):1425-32. Anticancer Res. 2006. PMID: 16619554 Clinical Trial.
-
[Combination of levofolinate calcium and 5-fluorouracil].Gan To Kagaku Ryoho. 2000 Feb;27(2):315-22. Gan To Kagaku Ryoho. 2000. PMID: 10700909 Review. Japanese.
-
[Irinotecan in combination for colon cancer].Bull Cancer. 1998 Dec;Spec No:43-6. Bull Cancer. 1998. PMID: 9932084 Review. French.