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. 2001 Oct;7(5):487-92.
doi: 10.1080/135502801753170354.

CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes

K Nakagaki  1 , K Nakagaki, K Takahashi, D Schols, E De Clercq, T Tabira
Affiliations

CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes

K Nakagaki et al. J Neurovirol. 2001 Oct.

Abstract

Feline astrocytes were productively infected with the Crandell feline kidney (CrFK) cell-adapted feline immunodeficiency virus (FIV) Petaluma strain in a primary culture. They expressed mRNA of CXCR4, and the FIV infection was blocked by stromal cell-derived factor 1alpha (SDF-1alpha), SDF-1beta, or the bicyclam AMD3100 in a dose-dependent manner. These observations suggest that, like FIV infection in CrFK cells and lymphocytes, the virus uses CXCR4 as a primary receptor for infecting astrocytes and this can be a possible natural model for AIDS dementia complex.

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References

    1. Neurosci Lett. 1998 Jun 19;249(2-3):163-6 - PubMed
    1. J Immunol. 1999 Aug 1;163(3):1636-46 - PubMed
    1. N Engl J Med. 1995 Apr 6;332(14):934-40 - PubMed
    1. J Gen Virol. 1994 May;75 ( Pt 5):979-87 - PubMed
    1. Science. 1990 Aug 3;249(4968):549-53 - PubMed

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