Review
doi: 10.1038/35093564.
Engineering chromosomal rearrangements in mice
Affiliations
- PMID: 11584294
- DOI: 10.1038/35093564
Item in Clipboard
Review
Engineering chromosomal rearrangements in mice
Nat Rev Genet.
2001 Oct.
Abstract
The combination of gene-targeting techniques in mouse embryonic stem cells and the Cre/loxP site-specific recombination system has resulted in the emergence of chromosomal-engineering technology in mice. This advance has opened up new opportunities for modelling human diseases that are associated with chromosomal rearrangements. It has also led to the generation of visibly marked deletions and balancer chromosomes in mice, which provide essential reagents for maximizing the efficiency of large-scale mutagenesis efforts and which will accelerate the functional annotation of mammalian genomes, including the human genome.
Similar articles
-
A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination.Nat Genet. 1995 Apr;9(4):376-85. doi: 10.1038/ng0495-376. Nat Genet. 1995. PMID: 7795643
-
Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells.Genomics. 2004 Jun;83(6):1072-82. doi: 10.1016/j.ygeno.2003.12.015. Genomics. 2004. PMID: 15177560
-
Introducing defined chromosomal rearrangements into the mouse genome.Methods. 2001 May;24(1):81-94. doi: 10.1006/meth.2001.1160. Methods. 2001. PMID: 11327806
-
Cre/loxP-mediated chromosome engineering of the mouse genome.Handb Exp Pharmacol. 2007;(178):29-48. doi: 10.1007/978-3-540-35109-2_2. Handb Exp Pharmacol. 2007. PMID: 17203650 Review.
-
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century.Nat Rev Genet. 2005 Jun;6(6):507-12. doi: 10.1038/nrg1619. Nat Rev Genet. 2005. PMID: 15931173 Review.
Cited by
-
Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9.J Mol Cell Biol. 2015 Aug;7(4):284-98. doi: 10.1093/jmcb/mjv016. Epub 2015 Mar 10. J Mol Cell Biol. 2015. PMID: 25757625 Free PMC article.
-
N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express.Microbiol Mol Biol Rev. 2005 Sep;69(3):426-39. doi: 10.1128/MMBR.69.3.426-439.2005. Microbiol Mol Biol Rev. 2005. PMID: 16148305 Free PMC article. Review.
-
A test for ectopic exchange catalyzed by Cre recombinase in maize.Theor Appl Genet. 2005 Jul;111(2):378-85. doi: 10.1007/s00122-005-2031-7. Epub 2005 May 24. Theor Appl Genet. 2005. PMID: 15912343
-
Contemporary approaches for modifying the mouse genome.Physiol Genomics. 2008 Aug 15;34(3):225-38. doi: 10.1152/physiolgenomics.90242.2008. Epub 2008 Jun 17. Physiol Genomics. 2008. PMID: 18559964 Free PMC article. Review.
-
Rearranging the centromere of the human Y chromosome with phiC31 integrase.Nucleic Acids Res. 2005 Oct 24;33(19):6101-13. doi: 10.1093/nar/gki922. Print 2005. Nucleic Acids Res. 2005. PMID: 16246911 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
