Review
doi: 10.1038/35096061.
The INK4a/ARF network in tumour suppression
Affiliations
- PMID: 11584300
- DOI: 10.1038/35096061
Item in Clipboard
Review
The INK4a/ARF network in tumour suppression
Nat Rev Mol Cell Biol.
2001 Oct.
Abstract
The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.
Similar articles
-
[Cyclin-dependent kinase 4 inhibitor a and tumor].Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001 Jun;18(3):219-21. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001. PMID: 11402455 Review. Chinese.
-
INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas.Oncogene. 2001 Oct 25;20(48):7104-9. doi: 10.1038/sj.onc.1204902. Oncogene. 2001. PMID: 11704835
-
The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements.Cancer Res. 2004 Jun 15;64(12):4122-30. doi: 10.1158/0008-5472.CAN-03-2519. Cancer Res. 2004. PMID: 15205322
-
Alterations of the INK4a-ARF gene locus in pleomorphic adenoma of the parotid gland.J Pathol. 2002 Nov;198(3):326-34. doi: 10.1002/path.1210. J Pathol. 2002. PMID: 12375265
-
Tumor suppression by Ink4a-Arf: progress and puzzles.Curr Opin Genet Dev. 2003 Feb;13(1):77-83. doi: 10.1016/s0959-437x(02)00013-8. Curr Opin Genet Dev. 2003. PMID: 12573439 Review.
Cited by
-
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.Biomed Res Int. 2020 Sep 28;2020:5425612. doi: 10.1155/2020/5425612. eCollection 2020. Biomed Res Int. 2020. PMID: 33062682 Free PMC article.
-
Oncomir miR-125b suppresses p14(ARF) to modulate p53-dependent and p53-independent apoptosis in prostate cancer.PLoS One. 2013 Apr 9;8(4):e61064. doi: 10.1371/journal.pone.0061064. Print 2013. PLoS One. 2013. PMID: 23585871 Free PMC article.
-
Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development.BMC Cancer. 2012 Feb 15;12:69. doi: 10.1186/1471-2407-12-69. BMC Cancer. 2012. PMID: 22336108 Free PMC article.
-
p53 ubiquitination: Mdm2 and beyond.Mol Cell. 2006 Feb 3;21(3):307-15. doi: 10.1016/j.molcel.2006.01.020. Mol Cell. 2006. PMID: 16455486 Free PMC article. Review.
-
Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor.EMBO J. 2005 Mar 23;24(6):1157-69. doi: 10.1038/sj.emboj.7600608. Epub 2005 Mar 10. EMBO J. 2005. PMID: 15775976 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
