Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2001 Nov;69(5):1146-8.
doi: 10.1086/323659.

The importance of genealogy in determining genetic associations with complex traits

Comparative Study

The importance of genealogy in determining genetic associations with complex traits

D L Newman et al. Am J Hum Genet. 2001 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure  1
Figure 1
Results of two genome scans—one including pedigree structure (lighter bars) and one not including pedigree structure (darker bars)—for IgE (a), LDL (b), and BMI (c). The five most significant loci when structure is included (left sides) and when structure is not included (right sides) are shown.
Figure  2
Figure 2
Number of significantly associated (P<.01) loci when pedigree structure is included (lighter bars) and when pedigree structure is not included (darker bars).

References

    1. Abney MA, McPeek MS, Ober C (2000) Estimation of variance components of quantitative traits in inbred populations. Am J Hum Genet 66:629–650 - PMC - PubMed
    1. ——— (2001) Narrow and broad heritabilities of quantitative traits in a founder population. Am J Hum Genet 68:1302–1307 - PMC - PubMed
    1. Bacanu SA, Devlin B, Roeder K (2000) The power of genomic control. Am J Hum Genet 66:1933–1944 - PMC - PubMed
    1. Badner JA, Sieber WK, Garver KL, Chakravarti A (1990) A genetic study of Hirschsprung disease. Am J Hum Genet 46:568–580 - PMC - PubMed
    1. Bitti PP, Murgia BS, Ticca A, Ferrai R, Musu L, Piras ML, Puledda E, Campo S, Durando S, Montomoli C, Clayton DG, Mander AP, Bernardinelli L (2001) Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in central Sardinia. Genet Epidemiol 20:271–283 - PubMed

LinkOut - more resources