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Comparative Study
. 2001 Jun;16(2):87-92.
doi: 10.3904/kjim.2001.16.2.87.

The effect of cilostazol on glucose tolerance and insulin resistance in a rat model of non-insulin dependent diabetes mellitus

S A Chang  1 , B Y Cha, S J Yoo, Y B Ahn, K H Song, J H Han, J M Lee, H S Son, K H Yoon, M I Kang, K W Lee, H Y Son, S K Kang
Affiliations
Comparative Study

The effect of cilostazol on glucose tolerance and insulin resistance in a rat model of non-insulin dependent diabetes mellitus

S A Chang et al. Korean J Intern Med. 2001 Jun.

Abstract

Background: It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined.

Methods: About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats.

Results: In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats.

Conclusion: These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.

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Figures

Figure 1.
Figure 1.
Plasma glucose (A) and insulin (B) concentrations in response to an intraperitoneal glucose challenge (2 g glucose/kg) in 6 month-old streptozotocin induced non-insulin dependent diabetic rats and normal control rats. Values presented as mean ± SEM.
Figure 2.
Figure 2.
Plasma glucose (A) and insulin (B) concentrations in response to an intraperitoneal glucose challenge (2g glucose/kg) in 7 month-old streptozotocin induced non-insulin dependent diabetic rats with 4 weeks of cilostazol treatment and their age-matched control rats. Values presented as mean ± SEM.
Figure 3.
Figure 3.
Fasting free fatty acid levels in normal control and streptozotocin induced non-insulin dependent diabetic rats before (6 months) and after (7 months) cilostazol treatment. Values presented as mean ± SEM.
Figure 4.
Figure 4.
Effects of cilostazol on glucose infusion rate in normal age-matched control and streptozotocin induced non-insulin dependent diabetic rats before (6 months) and after 4 weeks of cilostazol treatment (7 months). Values presented as mean ± SEM.
See this image and copyright information in PMC

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