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. 2001 Oct 22;11(20):2779-82.
doi: 10.1016/s0960-894x(01)00573-x.

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

A B Shahripour  1 , M S Plummer, E A Lunney, T K Sawyer, C J Stankovic, M K Connolly, J R Rubin, N P Walker, K D Brady, H J Allen, R V Talanian, W W Wong, C Humblet
Affiliations

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

A B Shahripour et al. Bioorg Med Chem Lett. .

Abstract

A series of compounds was designed and prepared as inhibitors of interleukin-1beta converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable interactions between the diphenyl ether rings and the prime side hydrophobic region. An X-ray crystal structure of a representative member of the diphenyl ether sulfonamide series bound to the active site of caspase-1 was obtained.

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