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. 2001 Sep 17;40(18):3284-3308.
doi: 10.1002/1521-3773(20010917)40:18<3284::aid-anie3284>3.0.co;2-u.

Catalyzed Asymmetric Arylation Reactions

Carsten Bolm  1 , Jens P. Hildebrand, Kilian Muñiz, Nina Hermanns
Affiliations

Catalyzed Asymmetric Arylation Reactions

Carsten Bolm et al. Angew Chem Int Ed Engl. .

Abstract

Addition and substitution reactions with carbon nucleophiles are fundamental processes in organic synthesis, and the development of general catalytic asymmetric variants thereof is still a major challenge today. In contrast to enantioselective alkyl transfer reactions, the corresponding arylations have not yet reached a high level of maturity. The existing protocols are either of no general applicability or are limited in terms of selectivity. This article summarizes established routes for catalytic asymmetric aryl transfer together with the latest developments in this area. The scope and limitations of this reaction are discussed.

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