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Clinical Trial
. 2001 Oct;21(5):484-7.
doi: 10.1097/00004714-200110000-00005.

A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia

D C Goff  1 , L Leahy, I Berman, T Posever, L Herz, A C Leon, S A Johnson, G Lynch
Affiliations
Clinical Trial

A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia

D C Goff et al. J Clin Psychopharmacol. 2001 Oct.

Abstract

CX516, a positive modulator of the glutamatergic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor, improves performance in tasks requiring learning and memory in animals. CX516 was added to clozapine in 4-week, placebo-controlled, dose-finding (N = 6) and fixed-dose (N = 13) trials. CX516 was tolerated well and was associated with moderate to large, between-group effect sizes compared with placebo, representing improvement in measures of attention and memory. These preliminary results suggest that CX516 and other "ampakines" hold promise for the treatment of schizophrenia.

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